Mild obstructive sleep apnoea: MAD [long-term treatment]


Ejemplo de Dispositivo de Avance Mandibular, de OrthoApnea

OrthoApnea Mandibular Advancement Device

Mandibular Advancement Device (MAD) treatment is more suitable as long-term therapy because of its effectiveness and better compliance to treatment.

Oral appliance therapy is based on a dental device designed to advance the mandible, thereby enlarging and stabilizing the oropharyngeal airway. The treatment improves sleepiness in obstructive sleep apnoea, although less so than with CPAP. Some earlier randomised studies in mild-to-moderate obstructive sleep apnoea comparing oral appliance therapy and CPAP have suggested that CPAP is the superior treatment option. However, a recent comparison of the two therapies in 126 patients with moderate obstructive sleep apnoea (mean AHI 25·6 [SD 12·3])76 showed that after 1 month, the two treatments had similar efficacy in sleepiness, driving simulator performance, and disease-specific quality of life. It’s clear that oral appliance therapy was superior to CPAP.

Overall, these data indicate that oral appliance therapy can be recommended as a firstline therapy for patients with mild, symptomatic obstructive sleep apnoea.

Management considerations for patients with mild obstructive sleep apnoea

A continuous positive airway pressure (CPAP) trial might be recommended in symptomatic patients, at least to ascertain whether or not normalization of sleep and respiration by CPAP leads to the relief of symptoms attributed to sleep-disordered breathing.

Oral appliances are a viable first-line therapist in mild obstructive sleep apnoea if feasible, especially from a dental point of view, and in patients who decline or do not respond to CPAP therapy.

Weight reduction and positional therapy are suitable management options for obese patients and those with positional obstructive sleep apnoea.

Surgical indications are rare in adults with obstructive sleep apnoea and largely confined to patients with a surgically correctable upper airway-obstructing pathology, such as adenotonsillar hypertrophy.

The following graph shows the effectiveness of CPAP and DAM by hours used per night and % of nights used. A greater number of patients used the device for more days and more hours.


Comparative efficacy and compliance of CPAP and oral appliance therapy in mild-to-moderate obstructive sleep apnoea

Mild obstructve sleep apnoea: clinical relevance and approaches to management

Obstructive sleep apnoea is highly prevalent in the general population worldwide, especially in its mild form. Clinical manifestations correlate poorly with disease severity measured by the apnoea-hypopnoea index (AHI), which complicates diagnosis. Full polysomnography might be more appropriate to assess suspected mild cases because limited ambulatory diagnostic systems are least accurate in mild disease.

Treatment options in mild obstructive sleep apnoea include continuous positive airway pressure (CPAP) and oral appliance therapy, in addition to positional therapy and weight reduction when appropriate. The superior efficacy of CPAP in reducing AHI is offset by greater tolerance of oral appliances, especially in mild disease.

Although severe obstructive sleep apnoea is associated with adverse health consequences, including cardio metabolic comorbidities, the association with mild disease is unclear, and reports differ regarding the clinical relevance of mild obstructive sleep apnoea. Improved diagnostic techniques and evidence-based approaches to management in mild obstructive sleep apnoea require further research.